Liquivent®

 

 


Liquivent® is a clear perfluorocarbon (PFC) solution for lung lavage - intended to aid in the removal of foreign material and tenacious bronchial secretions.


The water-clear, very dense, low-viscosity PFC liquid is immiscible with both water and lipids. Due to its high density it easily penetrates to the lowest levels in the lung to displace most solids* and liquids, causing those to float to the top of the meniscus where they are easily suctioned out.

*Solids such as food, smoke, charcoal, mucus & dust.

Liquivent Perfluorcarbon solution

Perfluorcarbon's (PFC) have been extensively studied in both the lungs and circulation. PFC's are bio-inert, minimally absorbed and have no deleterious histological cellular or biochemical effects1. PFC molecules are too large to be metabolised2 and are therefore non-reactive in the respiratory or circulatory system. In addition, PFC's have very high vapour pressures3 and evaporate quickly.


Clinical studies have shown that PFC's are eliminated from the lungs primarily by evaporation, with radiographic clearance of most of the PFC's by 48 hours1. In addition, PFC use in the lungs enhances surfactant phospholipid production4. Instillation of Perflubron into the lungs was found to actually diminish oxidation damage to injury prone tissues5, and when used with exogenous surfactant, PFC actually improved pulmonary gas exchange after meconium aspiration6

Liquivent

Liquivent® is available in both a radiopaque or radiolucent solution, and supplied in a variety of set volumes from a 20ml syringe to a 1L screw top bottle to accommodate an extensive patient range.

 

 

 

Radiopaque:

 

 

Radiolucent:

 

 

 

3ml Syringe:   

PFB-3

 

20ml Syringe:   

PFD-20

 

 

20ml Syringe: 

PFB-20

 

50ml Syringe:  

PFD-50 

 

 

50ml Syringe: 

PFB-50

 

125ml Bottle:   

PFD-125

 

 

125ml Bottle:  

PFB-125

 

250ml Bottle:    

PFD-250 

 

 

250ml Bottle:  

PFB-250

 

500ml Bottle:   

PFD-500

 

 

500ml Bottle:  

PFB-500

 

1000ml Bottle: 

PFD-1000

 

 

1000ml Bottle: 

PFB-1000

 

 

 

 

References
1. Reickert C, Pranikoff T, Overbeck M, Kazerooni E, Massey K, Bartlett R, Hirschl R. "The Pulmonary And Systemic Distribution And Elimination Of Perflubron From Adult Patients Treated With Partial Liquid Ventilation" 
Chest. 2001 Feb; 119(2):515-522

2. PFC Molecular weights > 480

3. Vapor pressure > 5.9 mbar @ 20 C

4. Steinhorn DM, Leach CL, Fuhrman BP, Holm BA. "Partial Liquid Ventilation Enhances Surfactant Phospholipid Production." Critical Care Med. 1996 Jul; 24(7):1252-6.

5. Rotta AT, Gunnarsson B, Fuhrman BP, Wiryawan B, Hernan LJ, Steinhorn DM. “Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.”Pediatr Crit Care Med. 2003 Apr;4(2):233-8.

6. Schlösser R, L, Veldman A, Fischer D, Funk B, Brand J, von Loewenich V. "Comparison of Effects of Perflubron and Surfactant Lung Lavage on Pulmonary Gas Exchange in a Piglet Model of Meconium Aspiration." Biol Neonate. 2002 Feb; 81:126–131